Synthesis and Antimicrobial Activity of Some Pyridinium Salts

WOS: 000273043200027PubMed ID: 20032886Some substituted benzylidenehydrazinylpyridinium derivatives bearing benzyl, ethylphenyl and propylphenyl groups on the pyridinium nitrogen were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using the microdilution method. Antimicrobial test results indicated that compounds containing a 3-phenylpropyl chain displayed the highest antimicrobial activity against Staphylococcus aureus and the compound 3d was the most active in the series against all tested bacteria and fungi strains.Ege University Scientific Research Project CouncilEge University [07/ECZ/007]This study was supported by Ege University Scientific Research Project Council (Project number: 07/ECZ/007)

Antibacterial activity of porphyrin derivatives against multidrug-resistant bacteria

Tasli, Huseyin/0000-0003-0216-1740WOS: 000493108500002PubMed: 31894020In this study, it was aimed to investigate the antibacterial activities of the cationic porphyrin derivatives against some multi drug resistant clinical bacterial isolates and standard strains for the development of potential antibacterial agents. in addition to the standard strains, methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa clinical isolates were studied. We synthesized eight (P1-P8) cationic porphyrin derivatives. the minimum inhibitory concentrations (MIC) of these substances were determined by micro dilution method. Ciprofloxacin was used for quality control. the study was repeated three times. All porphyrin derivatives exhibited antibacterial activity at different levels according to the studied bacteria. the strongest antibacterial activity was obtained with compounds P6, P7 and P8. These compounds were found to have MIC values of <5-156 mu g/ml. Because of the low MIC values, it has been concluded that these synthesized porphyrin derivatives may be high-potency agents against bacteria with high resistance profile

Photoinactivation with Novel Porphyrin Derivatives: An in Vitro Study on Multi-drug Resistant Escherichia coli

Medical Technologies National Congress (TIPTEKNO) -- OCT 12-14, 2017 -- TRABZON, TURKEYWOS: 000427649500081In the study, it was aimed to investigate the bactericidal activity of antimicrobial photodynamic therapy (aPDT) performed on in-vitro conditions with novel cationic-porphyrin derivatives (CPDs) on multidrug resistant E. coli. In aPDT experiments performed with different concentrations of photosensitizer and different energy densities, 99.9999% or more decrease in bacterial survival was detected. aPDT carried out with CPDs at concentrations below the MIC values has the potential to display a strong antimicrobial activity against the MDR E. coli clinical isolates.IEEE Turkey Sec